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St. Louisans hopeful as FDA approves groundbreaking gene therapies for sickle cell disease

Published Tue, 04 Mar 2025 08:46:56 GMT

ST. LOUIS - Friday was a monumental day for Americans battling a rare but painful disease. The Food and Drug Administration has approved two new gene therapies for patients with sickle cell disease. Studies show they are extremely effective, too. The news had patients, doctors, and advocates for those fighting the disease in the St. Louis area celebrating.The new, one-time gene therapy treatments are for sickle cell patients who are at least 12 years of age with severe forms of the disease. St. Charles ATM heist unraveled in high-tech crime trail The disease affects hemoglobin, the protein in red blood cells that carries oxygen. A genetic mutation causes the cells to become crescent-shaped, which can block blood flow. That can cause excruciating pain, organ damage, and stroke.An estimated 100,000 Americans live with the illness. St. Louisan Bonita Washington is one of them.“It is pain that we have no control over. The pain is real," Washington said.Washington said the painful atta...

Nuggets nearly erase 25-point deficit in fourth quarter but lose first home game of season to Rockets

Published Tue, 04 Mar 2025 08:46:56 GMT

Mercifully for the Nuggets, they don’t have to play the Rockets anymore.Four matchups in the first 23 games of the season? That’s more than enough. Three was enough. But in one last clash added to the schedule a week ago after they were eliminated from the in-season tournament, the Nuggets sputtered on offense for a half and defense for one quarter in a 114-106 loss to Houston on Friday night at Ball Arena.Denver (14-9) trailed 103-78 with 8:26 remaining but mounted a miraculous 18-0 run to get within seven with three minutes remaining. The Nuggets had the ball with a chance to cut it to five, but Alperen Sengun’s chippy defense against Nikola Jokic forced a turnover with 2:32 left. Houston finally scored by getting to the line at the other end, and the Nuggets ran out of gas as Jokic waged war with the officiating crew for how Sengun was defending him in crunch time.This was the Nuggets’ first home loss since Game 2 of the NBA Finals in June. It’s the ...

Suspect sought in Berkeley double stabbing

Published Tue, 04 Mar 2025 08:46:56 GMT

BERKELEY — Police on Friday night asked residents in Berkeley’s Claremont neighborhood to shelter in place while they searched for a suspect in a double stabbing.Related ArticlesCrime and Public Safety | Pleasant Hill neighborhood locked down for a second time in less than 24 hours Crime and Public Safety | Berkeley police video shows officer shooting suspect during November incident Crime and Public Safety | While Oakland’s 911 system was dangerously understaffed, 1,000 operator applications went unprocessed Crime and Public Safety | Pleasant Hill police surround former cop’s home after shooting, then just leave Crime and Public Safety | Two arrested in connection with downtown Walnut Creek robbery, pistol-whipping The stabbing happened around 6:30 p.m. near El Camino Real and the Oakridge Path, the Berkeley Police Department said in an advisory. Police did not release any information about the vi...

Concord apartments have been without water for 3 days

Published Tue, 04 Mar 2025 08:46:56 GMT

CONCORD, Calif. (KRON) -- Residents at an apartment complex in Concord are frustrated with ongoing water issues. They say they’ve been without running water for three days at Renaissance Square Apartments after a water pipe burst earlier this week, flooding several apartments.This isn’t the first time residents have complained. Police deem Pleasant Hill shelter-in-place subject who allegedly shot wife ‘no threat’ Renaissance Square Apartments in Concord describes it as a modern luxury, but residents say living here is anything but luxurious.It was not a good day when residents at Renaissance Square Apartments found this in one of the hallways -- a burst pipe that sent water into several apartments.“Water coming from the walls, coming down from the light fixtures, coming from the ceiling,” said resident Angela Williams. “It was just gushing under the door, so I used like all my blankets to prevent it from spreading further and damaging my personal belongings," said another resident...

San Francisco Giants sign Tsutsugo and Jefferies to minor league contracts

Published Tue, 04 Mar 2025 08:46:56 GMT

SAN FRANCISCO (AP) — Japanese first baseman and outfielder Yoshitomo Tsutsugo has agreed to a minor league contract with the San Francisco Giants that includes an invitation to spring training.Tsutsugo played in the club’s farm system this year and re-signed as a free agent. The 32-year-old last appeared in the majors for Pittsburgh in 2022, batting .171 with two homers and 19 RBIs in 50 games. He hit .260 with 10 home runs with 44 RBIs over 68 games this season between the Texas Rangers’ Triple-A Round Rock affiliate and San Francisco’s Double-A Richmond and Triple-A Sacramento teams.Also on Friday, right-hander Daulton Jefferies signed a minor league deal with San Francisco. The former Oakland pitcher will remain in the Bay Area as he recovers from a second Tommy John surgery performed on Sept. 9, 2022. Giants president of baseball operations Farhan Zaidi confirmed both moves.Jefferies, who went 1-7 in eight starts for Oakland in 2022, shared with The Associated ...

The Texas Supreme Court has paused an order that allowed a pregnant woman to have an abortion despite the state’s ban

Published Tue, 04 Mar 2025 08:46:56 GMT

AUSTIN, Texas (AP) — The Texas Supreme Court has paused an order that allowed a pregnant woman to have an abortion despite the state’s ban.Source

Chinakhov scores 2 in 3rd period as Blue Jackets beat Blues 5-2

Published Tue, 04 Mar 2025 08:46:56 GMT

COLUMBUS, Ohio (AP) — Yegor Chinakhov scored twice in the third period, Jet Greaves stopped 41 shots for his first NHL victory, and the Columbus Blue Jackets beat the St. Louis Blues 5-2 Friday night to snap a three-game skid.Kirill Marchenko had a goal and an assist, and Adam Fantilli scored for his 16th point, putting him second behind Connor Bedard’s 21 for the league lead among rookies this season. Alexandre Texier had an empty-netter, Dmitri Voronkov added two assists and Chinakhov also had one.“It’s a really good game to build on for this group,” Greaves said. “Something we’ve talked about is making sure we close out games in the third, and I thought we did a great job with that.”Robert Thomas scored twice and Joel Hofer stopped 17 shots for the Blues, who have lost three of their last four games.“We had chances, but when you make mistakes, they capitalized on them,” Blues coach Craig Berube said. Columbus’ first goal was a team effort, as three players traded the puck in fron...

Gordon Hayward scores 24 points as hot-shooting Hornets hold off Scottie Barnes, Raptors 119-116

Published Tue, 04 Mar 2025 08:46:56 GMT

CHARLOTTE, N.C. (AP) — Gordon Hayward scored 24 points, Miles Bridges added 22 and the hot-shooting Charlotte Hornets survived Scottie Barnes’ triple-double to beat the Toronto Raptors 119-116 on Friday night.Terry Rozier had 21 points and 13 assists and rookie Brandon Miller scored 20 for the Hornets, who shot 55.7% from the field, 52% from beyond the 3-point arc and made 18 of 20 free throws.Barnes had 31 points, 10 assists and 10 rebounds for Toronto, but missed a shot at the buzzer that appeared as though it would have sent the game into overtime had it gone down. After the game, it was determined that Barnes’ foot was on the line, making it a 2-point attempt.Barnes’ triple-double was the third of his career and second this season.Pascal Siakam added 25 points for the Raptors, who trailed by 13 points to start the fourth quarter and rallied to take a five-point lead, only to squander it down the stretch.“It was just about not panicking,” Bridges said of battlin...

Towns scores 24 points, Gobert dominates inside in Timberwolves’ 127-103 victory over Grizzlies

Published Tue, 04 Mar 2025 08:46:56 GMT

MEMPHIS, Tenn. (AP) — Karl-Anthony Towns scored 24 points, Rudy Gobert had 16 points, 20 rebounds and six blocks and the NBA-leading Minnesota Timberwolves pulled away in the third quarter to beat the Memphis Grizzlies 127-103 on Friday night for their sixth straight victory.Mike Conley added 19 points and seven assists to help Minnesota improve to 17-4. Gobert had 20 rebounds for the second straight game.Troy Brown Jr., who replaced the injured Anthony Edwards early in the game, scored 20 points, connecting on 8 of 10 shots, including 4 of 6 from 3-point range.Edwards, Minnesota’s leading scorer at 25.7 points a game, left four minutes in because of right hip pointer and didn’t return. Edwards missed two recent games with the same injury.Jaren Jackson Jr. led Memphis with 21 points. Desmond Bane added 16, and David Roddy had 13.The Grizzlies are without star guard Ja Morant while he serves a 25-game suspension to start the season. He was penalized for a second online video showing ...

Denver weather: Winter advisories into Saturday

Published Tue, 04 Mar 2025 08:46:56 GMT

DENVER (KDVR) — A Pinpoint Weather Alert Day has been issued for Friday for snowfall that started in the mountains and picked up in Denver's weather after sunset, with snowfall and colder temperatures to continue overnight.Winter weather advisories remain in effect until Saturday morning. Accumulating snow is forecast to reach:4-10 inches in the mountains4-8 inches in the Palmer Divide6-12 inches in the southern foothillsAccumulating snow could lead to slick and snow-covered roads. A winter storm warning remains in effect through Saturday morning for northern El Paso County for 3-9 inches of snowfall and wind gusts up to 40 mph, all contributing to very difficult travel with reduced visibility at times.Weather tonight: Snow showersOn Friday night, snow showers will pick up, especially in the foothills and Palmer Divide. Snowfall totals will only amount to 1-2 inches by the airport and 2-3 inches of snow in the city.The highest snowfall totals will be in the foothills and Palmer Div...